Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications.To be biologically active, such an oligonucleotide has to efficiently bind the target sequence.Here we used molecular dynamics simulations and electrophoresis mobility shift assay
This study contributes to the therapist variable in general and the personality Dugouts profile of securely and insecurely attached psychotherapists and other healthcare professionals in particular.In a preceding study, it has been found that insecurely attached psychotherapists differ in nine personality styles from securely attached ones.The aim
The discovery of cholelithiasis in neonates is often incidental, however obstructing common bile duct stones are rare.Herein we here report the case of a 3 week old neonate who presented with obstructive choledocholithiasis.The patient was treated conservatively with antibiotics and ursodeoxycholic acid but did not improve.He was therefore taken to
Only a few signaling pathways have been reported in germinal center (GC) B-cell proliferation and death.In this study, we showed that a novel uncharacterized Gm614 protein is highly expressed in GC B cells from lupus-prone mice.Critically, ablation of this GC B-cell-specific Gm614 promoted GC B-cell death and mitigation Socks of autoimmune symptoms
Gene duplication often provides selective advantages for the survival of microorganisms in adapting to varying environmental conditions.P.aeruginosa PAO1 possesses two seven-gene operons [phz1 (phzA1B1C1D1E1F1G1) and phz2 (phzA2B2C2D2E2F2G2)] that are involved Tool Set in the biosynthesis of phenazine-1-carboxylic acid and its derivatives.Although